Search results - 20 results
Safety assessment of titanium dioxide (E171) as a food additive
effects. With respect to genotoxicity, the Panel concluded that TiO2 particles have the potential to induce DNA strand breaks and chromosomal damage, but not gene mutations. No clear correlation was observed ...
Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide
modelling. Agglomerate size as a nanodescriptor was well associated with biological endpoints such as DNA damage and/or cytotoxicity. We conclude that, agglomerate size is an important nanodescriptor to assess ...
Identification of flavouring substances of genotoxic concern present in e-cigarette refills
induced gene mutations and chromosome damage in vitro, whereas equivocal results were obtained for the fourth compound. Thus, although there is a legislative framework which excludes the use of CMR ...
New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test
Emilio Source: Toxicology Letters, Volume 329, Number 84 (2020) Keywords: Chromosome damage genotoxicity In silico model In vivo micronucleus QSAR Abstract: A large number of computer-based prediction ...
Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo
exposed to these suspensions for 24 h and endpoints such as cytotoxicity, total glutathione, epithelial barrier integrity, inflammatory mediators and DNA damage were measured. Large agglomerates of 17 nm ...
Phytochemical screening, antioxidant, anticoagulant and in vitro toxic and genotoxic properties of aerial parts extracts of Fumaria officinalis L. growing in Tunisia
the bacterial Vitotox test. This was confirmed in the comet assay which was conducted on human C3A cells, except for the methanolic extract where DNA damage appeared to be significantly increased at ...
Comments on the “Evaluation of the Genotoxicity of Cell Phone Radiofrequency Radiation in Male and Female Rats and Mice Following Subchronic Exposure” by Smith‐Roe et al.
Number 295 (2020) Keywords: brain Comet Assay DNA Damage glioma Micronucleus assay Sprague Dawley Abstract: Comment on Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and ...
In vitro 50 Hz magnetic field long-term exposure: Cytogenetic tests on human lymphoblastoid TK6 cells and validation of the test environment
effects of long-term exposure to ELF-(E) MF s on the genetic material and the impact of long-term pre-exposure to ELF-(E) MF s on the sensitivity of cells to the damage induced by known mutagens are needed. ...
Confronting Risk of Bias in RF Bioeffects Research. Comments on Two Papers by Vijayalaxmi and Prihoda
https://doi.org/10.1667/ RR15478.1 In two meritorious published articles (1, 2), Vijayalaxmi and Prihoda reviewed 225 published laboratory studies with a total of 2,160 individual tests on genetic damage to mammalian cells ...
Assessing the endocrine activity of PAHs using the DRE-, ERE- and PPARγ CALUX bioassays
with our hormonal system by binding to endocrine receptors, resulting in adverse health effects such as reproductive damage, developmental impairment, obesity, diabetes and cancers. The aim of this study ...