Search results - 228 results

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

Source: Eur Respir J (2020) Abstract: Conventional molecular tests for detecting complex (MTBC) drug resistance on clinical samples cover a limited set of mutations. Whole genome sequencing (WGS) typically ...

Use of a Whole Genome Sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017-2019: an ECDC pilot study.

and lessons learned to be considered for the future development of a WGS-based surveillance system. WGS and epidemiological data of patients with rifampicin (RR) and multi-drug resistant ...

Superficial mycoses in Belgium: Burden, costs and antifungal drugs consumption

Issue 5, Number 508 (2020) Keywords: antifungal drugs consumption Belgium burden of disease Candidiasis Cost dermatophytosis Disability-Adjusted Life Years superficial mycosis Abstract: Background ...

Characterization and hazard identification of substandard and falsified antimicrobials encountered in Belgium

essential life-saving medicines could cause treatment failures, antimicrobial resistance and drug side effects [1]. Therefore, validated and robust analytical tools enabling the identification and ...

Comparative dissolution study on substandard and falsified antibiotics encountered in Belgium

resistance and drug side effects [1]. In general, the evaluation of SF antimicrobials mainly focuses on the identification and quantification of the active pharmaceutical ingredients (API s), ignoring other ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

has become a World Health Organization priority. We previously developed a software tool,, which provided offline species identification and drug resistance predictions for from whole genome sequencing ...

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

the knowledge on resistance mutations which is limited for especially 2nd-line and new drugs, (b) do not distinguish living from death cells, (c) ignore all intrinsic resistance mechanisms like efflux ...

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear. METHODS: We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

Pieter-Jan Ceyssens Source: 39th Annual Congress of the European Society of Mycobacteriology, Issue ESM, Dresden, Germany (2018) Keywords: drug susceptibility testing Mycobacterium tuberculosis Health Topics:  ...

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