Search results - 170 results

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

Source: Eur Respir J (2020) Abstract: Conventional molecular tests for detecting complex (MTBC) drug resistance on clinical samples cover a limited set of mutations. Whole genome sequencing (WGS) typically ...

Use of a Whole Genome Sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017-2019: an ECDC pilot study.

and lessons learned to be considered for the future development of a WGS-based surveillance system. WGS and epidemiological data of patients with rifampicin (RR) and multi-drug resistant ...

Characterization and hazard identification of substandard and falsified antimicrobials encountered in Belgium

essential life-saving medicines could cause treatment failures, antimicrobial resistance and drug side effects [1]. Therefore, validated and robust analytical tools enabling the identification and ...

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

the knowledge on resistance mutations which is limited for especially 2nd-line and new drugs, (b) do not distinguish living from death cells, (c) ignore all intrinsic resistance mechanisms like efflux ...

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear. METHODS: We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

Pieter-Jan Ceyssens Source: 39th Annual Congress of the European Society of Mycobacteriology, Issue ESM, Dresden, Germany (2018) Keywords: drug susceptibility testing Mycobacterium tuberculosis Health Topics:  ...

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

profiles; phenotypic resistance to isoniazid, rifampicin, ethambutol, pyrazinamide, and capreomycin; and corresponding drug resistance mutations. We whole-genome sequenced all Mycobacterium tuberculosis ...

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

Volume 22, Issue 1 (2018) Keywords: Carbapenems repurposed drugs XDR-TB Abstract: BACKGROUND: Extensively drug-resistant tuberculosis (XDR- TB), defined as TB caused by a Mycobacterium strain resistant to ...

Survey on the Use of Whole-Genome Sequencing for Infectious Diseases Surveillance: Rapid Expansion of European National Capacities, 2015-2016.

infectious diseases and antimicrobial drug resistance. It provides precise geographical delineation of spread and enables incidence monitoring of pathogens at genotype level. Coupled with epidemiological and ...

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