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Next-Generation Sequencing: An Eye-Opener for the Surveillance of Antiviral Resistance in Influenza

antivirals can lead to antiviral resistance mutations in the entire influenza genome. Therefore, the methods to detect these mutations should be developed and implemented. In this Opinion, we assess how NGS ...

Real-time prediction of influenza outbreaks in Belgium.

eventually reduce mortality and the costs induced by influenza-related absenteism. In Belgium, a network of Sentinel General Practitioners (SGP s) is in place for the early detection of the seasonal influenza ...

Co-circulation of influenza A(H1N1)pdm09 and influenza A(H3N2) viruses, World Health Organization (WHO) European Region, October 2018 to February 2019.

viruses circulated widely and detection levels in primary care and hospital settings were similar to past seasons. Hospitalisation data may suggest an increased susceptibility to A(H1N1)pdm09 virus in older ...

Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans

virulence in humans. An extensive PB2- UPS interplay has been detected that recapitulates the evolution of IAV s in humans. Functional validation with several IAV strains, including the seasonal H1N1 pdm09 ...

Incorporation of the influenza A virus NA segment into virions does not require cognate non-coding sequences.

substitutions in the 3' NC region were detected. With shorter sequences, insertions were observed in the 5' NC region. Restoration of viral fitness was linked to restoration of the NA ...

A general approach to identify low-frequency variants within influenza samples collected during routine surveillance.

population at sufficient depths to identify low-frequency variants (LFV) present in a quasispecies, but many challenges remain for reliable LFV detection because of experimental errors introduced during sample ...

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