Search results - 38 results

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

tests, the limit of detection was 100-1000 genome copies for fixed resistance mutations. Deeplex Myc- TB captured in silico 97.1-99.3% of resistance phenotypes correctly predicted by WGS from 3651 MTBC ...

Chemical and toxciological characterization of e-liquid cigarettes

quantitative in silico models. In total, potential genotoxicity activity was predicted for 44 flavourings. Based on information from European databases, genotoxicity could be confirmed for five of these ...

New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test

Emilio Source: Toxicology Letters, Volume 329, Number 84 (2020) Keywords: Chromosome damage genotoxicity In silico model In vivo micronucleus QSAR Abstract: A large number of computer-based prediction ...

Use of Whole Genome Sequencing Data for a First in Silico Specificity Evaluation of the RT-qPCR Assays Used for SARS-CoV-2 Detection.

were developed in January 2020 for initial in silico specificity evaluation and to verify whether the targeted loci are highly conserved. Now that more whole genome data have become available, we used ...

In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract

Hermans, Nina; Foubert, Kenn Source: Food and Chemical Toxicology (2019) Keywords: antigenotoxicity Erythrina latissima In vivo antihepatotoxic activity Leguminosae Prenylated flavonoids Abstract: Stem bark ...

Development of a sample preparation method for the GC-analysis of e-cigarette refill liquids

flavourings diacetyl and acetylpropionyl. The low and semi-volatiles contain potential genotoxic flavourings, selected through in-silico genotoxicity screening of 436 identified components in 77 e-liquid ...

Genotoxic evaluation of the liquids present in electronic cigarettes

performed with flavouring substances that have previously been identified in e-liquids. First, the genotoxic potential of these compounds was assessed using in silico prediction software Derek and Sarah ...

Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.

safety. By combining in silico predictions with existing in vitro and in vivo genotoxicity data from publicly available literature sources and results from in vitro gene mutation experiments, the 106 study ...

Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.

glycosyltransferase genes. This observation spurred the development of an in silico workflow which extracts the Shigella serotype from Next-Generation Sequencing (NGS) data, taking into account gene functionality. Both ...

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