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Brussels region finances VUB research into alternatives to animal experiments

would be carried out on cultures of human cells. The ultimate aim of that research is to find a treatment for fibrosis of the liver – the most common form of liver disease. This research receives a grant ...

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food

neurodevelopment, the liver, thyroid hormone homeostasis and the reproductive and immune systems. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour in mice can be considered the critical ...

Carry-over of some Fusarium mycotoxins in tissues and eggs of chickens fed experimentally mycotoxin-contaminated diets

Volume 145 (2020) Keywords: Broiler chickens Carry-over Egg feed Fusariotoxins Laying hens Liver Meat Muscle SKIN Abstract: Fusarium mycotoxins are fungal contaminants found in different crops intended for ...

Risk assessment of chlorinated paraffins in feed and food

experimental animals were reviewed and the CONTAM Panel identified the liver, kidney and thyroid as the target organs for the SCCP and MCCP mixtures tested in repeated dose toxicity studies. Decreased pup ...

Risk assessment of aflatoxins in food

Aldert, Piersma; Routledge, Michael; Schlatter, Josef; Baert, Katleen; Gergelova, Petra; Wallace, Heather Source: EFSA Journal, Volume 18, Issue 3 (2020) Keywords: aatoxin cancer exposure food Liver margin ...

Increased surface area of halloysite nanotubes due to surface modification predicts lung inflammation and acute phase response after pulmonary exposure in mice

of lung inflammation. The pulmonary and hepatic acute phase responses were assessed by Serumamyloida mRNA levels in lung and liver tissue by real-time quantitative PCR. Pulmonary and systemic ...

Phytochemical analysis, antioxidant, anticoagulant and in vitro toxicity and genotoxicity testing of methanolic and juice extracts of Beta vulgaris L.

anticoagulant and genotoxic activities. Genotoxicity was studied with the bacterial Vitotox test and the alkaline comet assay involving human C3A liver cells. The methanolic extract had the highest phenolic and ...

In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract

8 days prior to AFB1 exposure (1 mg/kg). The ELBE group showed a decreased activity of ALP and γ- GT compared to the AFB1 group. Histopathological examination of the liver demonstrated ameliorative effects ...

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After ...

Short-term biodistribution and clearance of intravenously administered silica nanoparticles

was applied at a dose of 20 mg/kgbw, followed by autopsy after 6 and 24 hours. The main organs where silicon accumulated were liver and spleen. The silicon concentration significantly decreased in ...

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