Search results - 42 results
Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide
outcome of computational modelling. In this study, we aim to identify nanodescriptor(s) and biological endpoint(s) capable of predicting the toxicity of titanium-di-oxide (TiO2) NM s, and demonstrate how ...
Human challenge trial workshop: Focus on quality requirements for challenge agents, Langen, Germany, October 22, 2019.
development of vaccines. In controlled human infection models, human challenge agents are used to infect healthy volunteers, therefore, ethical considerations include that the exposure studies need to be safe ...
Modelling for Taenia solium control strategies beyond 2020
aimed at refining the post-2020 targets for control of T. solium for a new roadmap for neglected tropical diseases. In response, two groups working on taeniasis and cysticercosis mathematical models ...
Performance of in silico models for mutagenicity prediction of food contact materials
demonstrate that performance varies among the four models, but can be increased by applying a combination strategy. Furthermore, the importance of the applicability domain is illustrated. Limited performance to ...
MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.
study the impact of MALT1 on virus infection in the brain, using the attenuated ERA rabies virus in different models of MALT1 deficient mice. We reveal the importance of MALT1-mediated inflammation and ...
Invasion by the Alien Tree Alters Ecosystem Functions in a Temperate Deciduous Forest
black cherry biogeochemical cycles biological invasion canopy foliar nutrients exotic species heterotrophic respiration invasive species litter Abstract: Alien invasive species can affect large areas, ...
Attenuation of RNA viruses by redirecting their evolution in sequence space.
Neutralizing Antibodies, Viral Codon Codon, Nonsense Coxsackievirus Infections Disease Models, Animal Dogs Enterovirus B, Human HEK293 Cells HeLa Cells Humans Influenza A Virus, H1N1 Subtype Madin Darby Canine ...
Mechanisms Linking Colorectal Cancer to the Consumption of (Processed) Red Meat: A Review.
Keywords: Animals Carcinogens Colorectal Neoplasms Diet Disease Models, Animal Food Handling Heterocyclic Compounds Humans Lipid Peroxidation Meat Products Polycyclic Aromatic Hydrocarbons Red Meat Risk ...
Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability.
(2016) Keywords: Administration, Cutaneous Animals Biological Availability Consumer Product Safety Cosmetics Dose-Response Relationship, Drug Humans Models, Molecular Molecular Structure ...
Determinants of the Bovine Leukemia Virus Envelope Glycoproteins Involved in Infectivity, Replication and Pathogenesis.
Interaction of viral envelope proteins with host cell membranes has been extensively investigated in a number of systems. However, the biological relevance of these interactions in vivo has been hampered by the ...