Search results - 4 results

Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide

outcome of computational modelling. In this study, we aim to identify nanodescriptor(s) and biological endpoint(s) capable of predicting the toxicity of titanium-di-oxide (TiO2) NM s, and demonstrate how ...

Human challenge trial workshop: Focus on quality requirements for challenge agents, Langen, Germany, October 22, 2019.

development of vaccines. In controlled human infection models, human challenge agents are used to infect healthy volunteers, therefore, ethical considerations include that the exposure studies need to be safe ...

Performance of in silico models for mutagenicity prediction of food contact materials

demonstrate that performance varies among the four models, but can be increased by applying a combination strategy. Furthermore, the importance of the applicability domain is illustrated. Limited performance to ...

MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.

study the impact of MALT1 on virus infection in the brain, using the attenuated ERA rabies virus in different models of MALT1 deficient mice. We reveal the importance of MALT1-mediated inflammation and ...

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