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Engineering nucleases for gene targeting: safety and regulatory considerations.

available about off-target effects associated with the use of this approach. We discuss how NBGT may offer a new perspective for genetic modification, we address some aspects crucial for a safety improvement ...

Event report: SynBio Workshop (Paris 2012)- Risk assessment challenges of Synthetic Biology

Discussion Emerging risks Europe European European Commission European countries Field food Food Safety genetic modification GMOs health identify INFORMATION Institute International journal Monitoring national ...

Chlamydia Psittaci, Causative Agent of Avian Chlamydiosis and Human Psittacosis: Risk Assessment and Biosafety Recommendations for Laboratory Use

Volume 17, Issue 2, Number 88, p.82- 88 (2012) Keywords: Abattoirs Agent article AS assessment bacteria biosafety cell culture cells CONTACT containment disease environment general genetic modification ...

Motif switches: decision-making in cell regulation.

These interactions underlie the ability of proteins to make decisions by combining regulatory information encoded in a protein’s expression level, localisation and modification state. This raises the ...

Population pharmacokinetic modeling and optimal sampling strategy for Bayesian estimation of amikacin exposure in critically ill septic patients88

Toxicology treatment Volume Abstract: Because the sepsis-induced pharmacokinetic (PK) modifications need to be considered in aminoglycoside dosing, the present study aimed to develop a population PK model for ...

Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 24386

potency than EM-2 which confirmed the usefulness of structural modifications in obtaining new leads for pain-relief therapeutics Service:  Quality of laboratories Kwaliteit van laboratoria Qualité des ...

Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4

mechanism to regulate inflammation. In this study, we describe modification of the CXC chemokine stromal cell-derived factor 1alpha/ CXCL12 by peptidylarginine deiminase (PAD) that converts arginine residues ...

Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure4392

the mu-opioid receptor and thus represent a potential framework for modification into mu-antagonists. Here we report on the synthesis and biological evaluation of novel [d-2-Nal(4)]endomorphin-2 ...

Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.

eosinophil-rich airway inflammation, airway hyperreactivity and airway wall modifications known as remodelling. We previously demonstrated that the spores of two allergenic moulds, Alternaria alternata and ...

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