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Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.
respectively. All discrepancies were analyzed with whole-genome sequencing and shown to be related to causative mutations (stop codons, indels, and promoter mutations) in glycosyltransferase genes. This ...
Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing
Mutation frequencies and single nucleotide polymorphisms were used for comparisons to address the level of natural intrinsic heterogeneity of influenza A viruses. Clear differences in single nucleotide ...
Molecular epidemiology and antimicrobial resistance mechanisms of Campylobacter coli from diarrhoeal patients and broiler carcasses in Belgium.
gene among tetracycline-resistant isolates and the 23S rRNA A2075G mutation among erythromycin- resistant isolates. Furthermore, some erythromycin-resistant isolates harboured a diverse array of ...
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents. For each isolate, mutations associated with drug resistance and drug susceptibility were ...
Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium.
independent clinical bloodstream isolates. One strain was found to be micafungin resistant due to a mutation in the gene. Fluconazole resistance remained stable throughout the period and was observed in 20 ...
Risk factors and impact of allergic bronchopulmonary aspergillosis in Pseudomonas aeruginosa-negative CF patients.
mutation (homozygous or heterozygous), and Pa colonization. RESULTS: Median FEV at the year of diagnosis (index year) was significantly lower in patients with ABPA. The median of cumulative values of FEV and ...
The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis.
patients determined by Xpert can be treated with a rifabutin-containing regimen. Methods: Rifabutin susceptibility by rpoB mutation was assessed in 349 individuals from South Africa and 172 from Belgium. ...
Roadbook for the implementation of next-generation sequencing in clinical practice in oncology and hemato-oncology in Belgium.
discovery of DNA mutations associated with diagnosis and prognosis. It also aids in the development of targeted therapies to specific mutations and the rise of personalized medicine. As part of molecular ...
Genetic Basis and Clonal Population Structure of Antibiotic Resistance in Isolated From Broiler Carcasses in Belgium.
resistant isolates. Regarding resistance to erythromycin, different mutations occurred in diverse genetic loci, including mutations in the 23S rRNA gene, the and ribosomal genes, and the intergenic region ...
A liquid bead array for the identification and characterization of fljB-positive and fljB-negative monophasic variants of Salmonella Typhimurium.
required. In addition, identification of the mutations affecting expression of the flagellar gene fljB can be useful to support the monophasic character observed phenotypically. Finally, genetic subtyping of ...