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Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
Agents Cell Line Cysteine Endopeptidases Drug Evaluation, Preclinical Genes, Reporter Humans Luciferases, Firefly Picornaviridae Protease Inhibitors Viral Proteins Abstract: Proteolytical cleavage of the ...
2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.
(FMDV). FMDV belongs to the Picornaviridae and has the potential to cause devastating epidemics in livestock. The 50% and 90% effective concentrations (EC50 and EC90) for inhibition of the FMDV-induced ...