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Combined deficient response to polysaccharide-based and protein-based vaccines predicts a severe clinical phenotype

Publication Type: Peer reviewed scientific article Authors: Cockx, Maaike; Haerynck, Filomeen; Hoste, Levi; Schrijvers, Rik; Van der Werff ten Bosch, Jutte; Dillaerts, Doreen; Thomas, Debby; Schaballie, Heidi; Bucciol, Giorgia; Robberechts, Wiert; Patel, ...

ELM-the Eukaryotic Linear Motif resource-2024 update.

structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as ...

The phage-encoded PIT4 protein affects multiple two-component systems of Pseudomonas aeruginosa

urgently needed to develop alternative therapies. One path explored in this article is the use of bacteriophages and, more specifically, phage-derived proteins. In this study, a phage-derived protein was ...

Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions.

Pritisanac, Iva; Tenorio, Luiggi; Viennet, Thibault; Tompa, Peter; Vranken, Wim; Tosatto, Silvio C E; Davey, Norman E Source: Nat Methods, Volume 20, Issue 9 (2023) Keywords: Intrinsically Disordered Proteins ...

Applicability of the DPRA on mixture testing: challenges and opportunities.

Keywords: Animal Testing Alternatives Animals Peptides Abstract: The in chemico direct peptide reactivity assay (DPRA) is validated to assess protein reactivity of chemical compounds, relating to the ...

Development of a Droplet Digital PCR to Monitor SARS-CoV-2 Omicron Variant BA.2 in Wastewater Samples

RT-ddPCR method that targets the T19I amino acid mutation in the spike protein of the SARS-CoV-2 genomes, which is specific to the BA.2 variant (omicron). The T19I assay was evaluated both in silico and in ...

Identification of Mycobacterium abscessus Subspecies by MALDI-TOF Mass Spectrometry and Machine Learning.

challenging. In this study, a collection of 325 clinical isolates of M. abscessus was used for MALDI- TOF MS analysis and for the development of machine learning predictive models based on MALDI- TOF MS protein ...

Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics

Publication Type: Peer reviewed scientific article Authors: Zhou, Zhiyu; Wattiez, Ruddy; Constant, Patricia; Marrakchi, Hedia; Karine Soetaert; Vanessa Mathys; Fontaine, Véronique; Zeng, Sheng Source: Microorganisms, Volume 11, Issue 10 (2023) Health Topi ...

MALDI-TOF Mass Spectrometry Online Identification of Using the MSI-2 Application.

MSI-2 MALDI- TOF identification tool in order to identify. By multiplying the culture conditions (2 culture media and 6 stages of growth) prior to protein extractions for both test isolates and reference ...

Assessment of the Feasibility of a Future Integrated Larger-Scale Epidemiological Study to Evaluate Health Risks of Air Pollution Episodes in Children.

disorders in children. Using sensitive biomarkers helps to assess the impact of air pollution on children’s respiratory health and combining protein, genetic and epigenetic biomarkers gives insights on their ...

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