Search results - 14 results

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

phenotypic results involved pyrazinamide, ethambutol, and ethionamide, and low-level rifampicin- or isoniazid-resistance mutations, all notoriously prone to phenotypic testing variability. Only 2 of 91 (2.2%) ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

provides the same functionality based on a new software implementation. Improvements include i) an updated mutation catalogue giving greater sensitivity to detect pyrazinamide resistance, ii) support for ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

v and clinical Mtb strains on ten anti- TB drugs including Bedaquiline, Pyrazinamide and Delamanid was determined, to identify RNA Biomarkers. In a next phase, the RNA-based DST was developed in 96 well ...

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

the first-line antituberculosis drugs isoniazid, rifampin, ethambutol, and pyrazinamide for isolates from 16 countries across six continents. For each isolate, mutations associated with drug resistance ...

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

profiles; phenotypic resistance to isoniazid, rifampicin, ethambutol, pyrazinamide, and capreomycin; and corresponding drug resistance mutations. We whole-genome sequenced all Mycobacterium tuberculosis ...

External quality assessment for tuberculosis diagnosis and drug resistance in the European Union: A five year multicentre implementation study

performance prevention problems Pyrazinamide Quality QUALITY ASSURANCE resistance result results SB- IM specific State States study Sweden System Systems Test TESTING training Tuberculosis United Kingdom ...

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study9

outcome paris pathogen Patient Patient Care patients pharmacology portugal proportion protocol public public health Public-health Pulmonary Pyrazinamide region resistance result results SB- IM SCREENING ...

False-positive rifampicin resistance on Xpert® MTB/RIF caused by a silent mutation in the rpoB gene.

Isoniazid Male Molecular Sequence Data Mutation Mycobacterium tuberculosis Phenotype Pyrazinamide Rifampin Sensitivity and Specificity sputum Tuberculosis, Pulmonary Abstract: The Xpert® MTB / RIF assay ...

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