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Use of Whole Genome Sequencing Data for a First in Silico Specificity Evaluation of the RT-qPCR Assays Used for SARS-CoV-2 Detection.

Nucleotide Real-Time Polymerase Chain Reaction RNA Replicase RNA, Viral Sensitivity and Specificity whole genome sequencing Abstract: The current CO ronaVIrus Disease 2019 (COVID-19) pandemic started in ...

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

Cercopithecus aethiops Enterovirus B, Human HeLa Cells Humans Poliovirus RNA Replicase Viral Proteins Abstract: The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., ...

Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.

Substitution Animals Antiviral Agents Classical Swine Fever Classical swine fever virus Enzyme Inhibitors Genetic Variation Imidazoles Pyridines RNA Replicase Swine Viral Proteins Abstract: Classical swine fever ...

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

Mutation, Missense RNA Replicase triazoles Viral Proteins Virus Replication Yellow fever virus Abstract: [7-[3-(1,3-Benzodioxol-5-yl)propyl]-2-(2-furyl)-7H-pyrazolo [4,3-e][1,2,4]triazolo ...

Non coding extremities of the seven influenza virus type C vRNA segments: effect on transcription and replication by the type C and type A polymerase complexes.

Replication Influenzavirus C Molecular Sequence Data Nucleoproteins RNA Replicase RNA, Viral Templates, Genetic Transcription, Genetic Untranslated Regions Viral Proteins Abstract: BACKGROUND: The ...

Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.

Three-Dimensional Imidazoles Inhibitory Concentration 50 Models, Molecular Molecular Structure polymerase chain reaction Pyridines RNA Replicase RNA, Viral Sequence Analysis, DNA Structure-Activity Relationship Virus ...

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.

Replicase RNA, Viral Triazines Tumor Cells, Cultured Virus Replication Abstract: We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo ...

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