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Assessing the receptor-mediated activity of PAHs using AhR-, ERα- and PPARγ- CALUX bioassays

s have multiple modes of action and can activate/inhibit multiple receptor signaling pathways known to play critical roles in mediating endocrine disruption. Health Topics:  Health and disease monitoring ...

Migration of mineral oil from cardboard packaging for food: Identification of the hazards and assessment of the exposure of the Belgian population

Furthermore, preliminary results suggest the possible use of bioassays based on activation of the Aryl receptor as a fast screening procedure to detect the presence of MOAH, but more research is needed to ...

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice.

protease that mediates the activation of several innate and adaptive immune cells in response to multiple receptors, and therapeutic MALT1 targeting is believed to be a valid approach for autoimmunity and ...

Multivalent binding of herpesvirus to living cells is tightly regulated during infection.

8 (2018) Abstract: Viral infection, initiated by the landing of a virion on a cellular surface, is largely defined by the preliminary interactions established between viral particles and their receptors at ...

Activity-Based Detection and Bioanalytical Confirmation of a Fatal Carfentanil Intoxication.

a fatality in Norway. Blood, urine and vitreous, obtained during autopsy, were screened with a newly developed opioid activity reporter assay able to detect compounds based on their μ-opioid receptor activity ...

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

health Public-health Receptor response Responses result results Service Species strain structure study sugar Synthetic System TDM Term Tuberculosis vaccine vaccines WIV-ISP Abstract: The cell wall of ...

Innate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for development of adjuvants for subunit vaccines

Rather, the nature of the sugar and the number of acyl chains bound to it seem to dictate the affinity of the glycolipid for Mincle receptor in vitro. In vivo, we observed that TDM, TMM and GMM induce ...

PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes.

Kinase C-epsilon rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Transduction, Genetic Abstract: A critical role has been assigned to protein kinase C (PKC)ε in the control of intracellular ...

Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays.

Tumor Endocrine disruptors Genes, Reporter Humans Infant Equipment mice Polycarboxylate Cement Receptors, Cytoplasmic and Nuclear Abstract: Endocrine activity of 65 compounds migrating from polycarbonate ...

DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer.

Multivariate Analysis Pancreatic Neoplasms Prognosis Receptor, Notch1 Receptor, Notch3 Abstract: BACKGROUND: There is an increasing interest for Notch signalling pathway and particularly Delta-like ligand ...

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