Search results - 181 results

A bioinformatics WGS workflow for clinical complex isolate analysis, validated using a reference collection extensively characterized with conventional methods and approaches.

which a consensus framework is still largely absent. We developed a bioinformatics workflow for (Illumina) WGS-based routine typing of MTB Complex (MTBC) member isolates allowing complete characterization ...

Nusinersen treatment significantly improves hand grip strength, hand motor function and MRC sum scores in adult patients with spinal muscular atrophy types 3 and 4

available as the first treatment for Spinal Muscular Atrophy (SMA) and data on its effectiveness and safety in adult SMA patients are still scarce. Methods We evaluated the effectiveness and safety of ...

Urban environment and mental health: the NAMED project, protocol for a mixed-method studyIntroductionMethods and analysisEthics and dissemination

characteristics and mental health are still not well understood. These associations are highly complex and require an interdisciplinary and integrated research approach to cover the broad range of mitigating ...

Deepening of In Silico Evaluation of SARS-CoV-2 Detection RT-qPCR Assays in the Context of New Variants

future SARS-CoV-2 testing. Given the potential threat of the new variants, it is crucial to assess if they can still be correctly targeted by the primers and probes of the RT-qPCR assays. Our study ...

Tree pollen allergy risks and changes across scenarios in urban green spaces in Brussels, Belgium

spaces may be modified by environmental change is still not widely understood. This study analyzed tree inventory data of 18 urban green spaces (5940 trees; 278 taxa; 93 ha) in the Brussels Capital Region, ...

Impact of the revised European Tobacco Product Directive on the quality of e-cigarette refill liquids in Belgium

implementation of the revised TPD has improved the quality of the e-liquids on the Belgian market. However, there are still e-liquids that are not in agreement with the TPD due to nicotine concentration label ...

Influence of reduced levels or suppression of sodium nitrite on the outgrowth and toxinogenesis of psychrotrophic Clostridium botulinum Group II type B in cooked ham.

according to the EU legislation (Regulation (EC) No 1333/2008) can be reduced in cooked ham while still ensuring control of C. botulinum Group II type B. According to the multiple factors that could affect C. ...

Chemical and toxciological characterization of e-liquid cigarettes

found in the 2017-2018 samples compared to the samples before the TPD. In 2018, 5% of the samples contained caffeine, compared to 16% in 2017. The food flavours diacetyl and acetylpropionyl were still ...

Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination.

the detection of AMR genes; however, reliable reconstruction of plasmids is still a challenge due to large repetitive regions. This study proposes a workflow to reconstruct plasmids with NGS data in ...

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