Search results - 5 results
The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.
of phenotypic resistance was low for these drugs. Interpretation: This first WHO endorsed catalogue of molecular targets for MTBC drug susceptibility testing provides a global standard for resistance ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
a cluster of genes that encodes components of the FAS- II (fatty acid synthase II) complex, which is targeted by isoniazid. On the other hand, a remarkable down-regulation of the NADH-dehydrogenase (ndh) ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
synthase II) complex, which is targeted by isoniazid. On the other hand, a remarkable down-regulation of the NADH-dehydrogenase (ndh) cluster genes was noted. This can be assigned to the dependence of ...
RNA-based drug susceptibility testing of Mycobacterium tuberculosis
drug and RNA-targeting probes were designed. Next, the RNA-based DST was developed in 96 well format. In short, 200 µl of a positively flagged MGITTM (BD) culture is spiked with a drug, while a replicate ...
Transcriptional profiling of Mycobacterium tuberculosis suggests respiratory poisoning upon exposure to delamanid
Remarkably, the most highly induced genes comprise poorly characterized genes for which functional characterization might hint to the target molecule(s) of delamanid and its exact mode(s) of action. Health ...