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Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
Issue 2 (2023) Keywords: Algorithms Animals Biomarkers DNA Damage Gene Expression Profiling Humans Supervised Machine Learning Abstract: Transcriptomics-based biomarkers are promising new approach ...
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
approaches, we have developed an upgraded, innovative, and proprietary gene classifier. This gene classifier is based on transcriptomic changes induced by 12 genotoxic and 12 non-genotoxic reference compounds ...
In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.
Alessandra; Milushev, Dimiter; Benfenati, Emilio; Rogiers, Vera; Doktorova, Tatyana Y Source: Mutagenesis, Volume 31, Number 461, p.453-61 (2016) Keywords: Cosmetics In silico Mutagenicity Tests Transcriptomics ...