Search results - 12 results

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among patients from the Horn of Africa ...

Molecular epidemiology of Mycobacterium tuberculosis complex in Brussels, 2010-2013.

Surveillance Tuberculosis Tuberculosis, Multidrug-Resistant Urban Health Young adult Abstract: The tuberculosis (TB) incidence rate in Brussels-Capital Region is 3-fold higher than in Belgium as a whole. Eight ...

Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains.

epidemic. Here we analysed the transmission capacity of these strains in the context of their phylogenetic background and drug resistance mutations. The study collection included all multidrug resistant (MDR) ...

Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China.

Mycobacterium tuberculosis Rifampin Tuberculosis, Multidrug-Resistant Abstract: Mycobacterium tuberculosis can acquire resistance to rifampin (RIF) through mutations in the rpoB gene. This is usually accompanied ...

Synthesis and anti-tubercular activity of N(2)-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides.

Sensitivity Tests Molecular Conformation Mycobacterium tuberculosis Structure-Activity Relationship Tuberculosis, Multidrug-Resistant Abstract: Tuberculosis has remained a challenge for medicinal chemists ...

Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multi-drug resistant mycobacteria36969

observed that glycopeptides strongly inhibited PDIM deprived mycobacteria. Vancomycin together with a drug targeting lipids synthesis inhibited multidrug-resistant (MDR) and extensively-drug resistant (XDR) ...

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study9

Service Short SOFTWARE Spain standards Streptomycin study Sweden Switzerland Technique TESTING The Netherlands therapeutic use time treatment Treatment Outcome Tuberculosis Tuberculosis,Multidrug-Resistant ...

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage20

massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from ...

Anti-mycobacterial activity of 1,3-diaryltriazenes.

and multi-drug resistant M. tuberculosis. The results suggest the molecule to be an interesting scaffold for further study and optimization. Health Topics:  Health and disease monitoring Category:  A1 ...

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