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Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
recent report of the WHO ranks tuberculosis (TB) alongside HIV as a leading cause of death by infectious diseases. In combination, the spread of (multi-)drug resistant Mycobacterium tuberculosis is rising ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
(TB) alongside HIV as a leading cause of death by infectious diseases. In combination, the spread of (multi-)drug resistant Mycobacterium tuberculosis is rising (480 000 new cases), impeding the ...
Para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis33991
multidrug-resistant tuberculosis. Although it has been in clinical use for over 60 years, its mechanism(s) of action remains elusive. Here we report that PAS is a prodrug targeting dihydrofolate reductase (DHFR) ...
From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study.
Male Mutation Mycobacterium tuberculosis REGISTRIES Treatment Outcome Tuberculosis, Multidrug-Resistant Young adult Abstract: BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR- TB) ...
Biological evaluation of bisbenzaldehydes against four Mycobacterium species.
microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two ...
Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.
the pyrazinamidase (pncA) gene of a collection of multidrug-resistant tuberculosis (MDR- TB) clinical isolates and PZA-resistant (PZA (r)) spontaneous mutants. The frequency of acquired resistance to ...
Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study36555
Tuberculosis,Multidrug-Resistant welfare Abstract: Drug resistance and molecular epidemiology of tuberculosis (TB) in the Murmansk region was investigated in a 2-year, population-based surveillance of the civilian population. ...
Role of mutations in dihydrofolate reductase DfrA (Rv2763c) and thymidylate synthase ThyA (Rv2764c) in Mycobacterium tuberculosis drug resistance
n resistance Role SB- IM Tetrahydrofolate Dehydrogenase therapeutic use Thymidylate Synthase Tuberculosis Tuberculosis,Multidrug-Resistant Abstract: n Service: Bacterial diseases Maladies bactériennes ...
Surveillance of extensively drug-resistant tuberculosis in Europe, 2003-200736860
second-line drug (SLD) susceptibility tests among multidrug-resistant tuberculosis (MDR TB) cases reported in 20 European countries aiming to identify extensively drug-resistant tuberculosis (XDR TB) cases. ...
Population-based molecular epidemiological study of tuberculosis in Malatya, Turkey36781
between 2000 and 2004 in Malatya, Turkey. Drug susceptibility results indicated a total of 20% resistant and 4.8% of multidrug-resistant isolates. Spoligotyping resulted in 25 unique patterns and 120 ...