Search results - 28 results

Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multi-drug resistant mycobacteria36969

observed that glycopeptides strongly inhibited PDIM deprived mycobacteria. Vancomycin together with a drug targeting lipids synthesis inhibited multidrug-resistant (MDR) and extensively-drug resistant (XDR) ...

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study9

Service Short SOFTWARE Spain standards Streptomycin study Sweden Switzerland Technique TESTING The Netherlands therapeutic use time treatment Treatment Outcome Tuberculosis Tuberculosis,Multidrug-Resistant ...

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage20

massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from ...

Anti-mycobacterial activity of 1,3-diaryltriazenes.

and multi-drug resistant M. tuberculosis. The results suggest the molecule to be an interesting scaffold for further study and optimization. Health Topics:  Health and disease monitoring Category:  A1 ...

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

Molecular Structure Mycobacterium tuberculosis Pyrimidinones Quinones Structure-Activity Relationship Tuberculosis, Multidrug-Resistant Abstract: Given the re-emergence of tuberculosis in Europe and beyond, ...

1,2,3,4,8,9,10,11-Octahydrobenzo[j]phenanthridine-7,12-diones as New Leads against Mycobacterium tuberculosis

Research resistance Service strain study Target toxicity Tuberculosis vaccine vaccines Abstract: Tuberculosis (TB) continues to be a worldwide health problem with over 1.4 million deaths each year. Despite ...

Para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis33991

multidrug-resistant tuberculosis. Although it has been in clinical use for over 60 years, its mechanism(s) of action remains elusive. Here we report that PAS is a prodrug targeting dihydrofolate reductase (DHFR) ...

From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study.

Male Mutation Mycobacterium tuberculosis REGISTRIES Treatment Outcome Tuberculosis, Multidrug-Resistant Young adult Abstract: BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR- TB) ...

Biological evaluation of bisbenzaldehydes against four Mycobacterium species.

microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two ...

Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.

the pyrazinamidase (pncA) gene of a collection of multidrug-resistant tuberculosis (MDR- TB) clinical isolates and PZA-resistant (PZA (r)) spontaneous mutants. The frequency of acquired resistance to ...

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