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Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs.

emergency vaccines during outbreaks of foot-and-mouth disease. Antiviral drugs could be used as a complementary measure. This study aimed at developing a small animal model to assess the in vivo activity of ...

Anti-TNF-alpha therapy does not ameliorate disease in a model of acute virus-endotoxin mediated respiratory disease in pigs36852

Coronavirus cytology Development differences disease Disease Models,Animal Diseases DRUG drug therapy drugs effect effects electronic Faculty Female Group Human Humans im Immunoglobulin Immunoglobulin ...

The positive adjuvant effect of chitosan on antigen-specific cell-mediated immunity after chickens vaccination with live Newcastle disease vaccine.

It has been demonstrated to be an effective absorption enhancer to improve mucosal delivery of peptide and protein drugs in human and mice. In poultry, mucosal administration of live vaccine has been ...

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

Substitution Animals Antiviral Agents Benzodioxoles Cattle Cell Line Diarrhea Virus 1, Bovine Viral Diarrhea Virus 2, Bovine Viral Drug Resistance, Viral Hepacivirus Inhibitory Concentration 50 Models, Molecular ...

Characterization of pathogenic and resistant genome repertoire reveals two clonal lines in Salmonella enterica subsp. enterica serovar Paratyphi B (+)-tartrate positive.

Dose-Response Relationship, Drug Drug Resistance, Bacterial Drug Resistance, Multiple, Bacterial Genetic Variation Germany Humans Microbial Sensitivity Tests Netherlands Oligonucleotide Array Sequence Analysis ...

Potential of antiviral therapy and prophylaxis for controlling RNA viral infections of livestock.

treatment and up to 12h post-infection. Such prophylactic/therapeutic antiviral drugs could complement emergency vaccination in a previously disease-free setting or be applied to treat valuable zoological ...

Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.

Res, Volume 77, Issue 2, p.114-9 (2008) Keywords: Amino Acid Substitution Animals Antiviral Agents Cell Line Classical swine fever virus Diarrhea Viruses, Bovine Viral Drug Resistance, Viral Imaging, ...

An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells.

Issue 5, p.380-91 (2007) Keywords: Amiloride B-Lymphocytes Caco-2 Cells Cell Differentiation Coculture Techniques Drug Carriers Epithelial Cells Humans immunohistochemistry Intestinal Mucosa Microscopy, ...

2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.

2’-C-MetCyt resulted in a (1.6-3.2)x10(3)-fold reduction of infectious virus yield. Time-of-drug addition experiments suggest that 2’-C-MetCyt interacts with viral replication at a time point that coincides ...

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