Search results - 21 results

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

mutations as associated with resistance, or consistent with susceptibility, for 13 WHO endorsed anti-tuberculosis drugs. 38,215 MTBC isolates with paired whole-genome sequencing and phenotypic drug ...

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

Here, we evaluated the Deeplex Myc- TB targeted deep sequencing assay for prediction of resistance to 13 anti-tuberculous drugs/drug classes, directly applicable on sputum. With MTBC DNA tests, the limit ...

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

phenotypic Drug Susceptibility Testing (DST) of M. tuberculosis (Mtb), multiple DNA-based methods were successfully introduced over the last years. Although these are fast and sensitive, they (a) are based on ...

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

at least rifampicin, isoniazid, any fluoroquinolone and one of the injectable anti-tuberculosis drugs, remains a worldwide public health threat. Among repurposed drugs empirically used for XDR- TB ...

Synthesis and anti-tubercular activity of N(2)-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides.

representative. Apart from the nano-molar anti-mycobacterial activity, the compound was able to target intracellular residing Mycobacterium tuberculosis and the susceptibility of a multi-drug-resistant strain ...

Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multi-drug resistant mycobacteria36969

clinical isolates. Our study puts glycopeptides in the pipeline of potential anti- TB agents and might provide a new antimycobacterial drug-screening strategy Service:  Bacterial diseases Maladies ...

Simultaneous determination of anti-tuberculosis drug levels in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry for subsequent Therapeutic Drug Monitoring

Toxicology and Therapeutic Drug Monitoring- IATDMCT Satellite Meeting 2014, NA, Issue IATDMCT, NA (2014) Keywords: alternative Anti tubercolosis drugs DRUG Drug Monitoring Human LC-MS/MS LEVEL levels Liquid ...

Anti-mycobacterial activity of 1,3-diaryltriazenes.

spread of the drug resistant tuberculosis has led to an ongoing demand for novel compounds for therapeutic use. Identification and study of compounds with the ability to inhibit Mycobacterium tuberculosis ...

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

most antibiotics and xenobiotics, the search for such new compounds is far from trivial. Further exacerbated by the rapid generation and spread of drug resistant M. tuberculosis and fuelled by the HIV ...

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