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State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

transfer vehicles, as used for both research and gene therapy applications, because of their stable integration in non-dividing and dividing cells and long-term transgene expression. Along with our ...

How to evaluate emerging technologies in cervical cancer screening?

questions. We observe that good guidelines on assessment of evidence for screening questions are currently lacking. Guidelines for diagnostic research (STARD), involving systematic application of the reference ...

Electron tomography of negatively stained complex viruses: application in their diagnosis.

Publication Type: Peer reviewed scientific article Authors: Jan Mast; Demeestere, Lien Source: Diagn Pathol, Volume 4 (2009) Keywords: eletron tomography negative staining paramyxovirus Parapoxvirus Abstract: BACKGROUND: Electron tomographic analysis can ...

Marginal structural models for partial exposure regimes.

severely misleading in such settings and have shown contradictory results. Inverse probability weighting for marginal structural models may instead be used but is not directly applicable because these models ...

Comparison of classical serotyping and PremiTest assay for routine identification of common Salmonella enterica serovars.

increased to 714 (94.7%), while all assay failures were cleared. Our conclusion is that, in its actual development stage, the application of the investigated kit to purified DNA samples offers a valuable ...

Brucella suis identification and biovar typing by real-time PCR.

described ones in real-time PCR assays applicable to low-biosafety conditions. Allelic profiles unique for each B. suis biovar were defined and the most relevant signatures were determined on a collection of ...

Critical aspects in implementing the OECD monograph No. 14 "the application of the principles of GLP to in vitro studies".

principles of good laboratory practice (GLP) were originally developed for application to animal-based toxicology studies. On the other hand, more and more studies involving in vitro test systems are performed ...

Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India.

feasible and affordable early detection and management methods is a public health priority. Five screening methods, naked eye visual inspection of the cervix uteri after application of diluted acetic acid ...

Evidence for the presence of Legionella bacteriophages in environmental water samples.

amplification, purification, and characterization procedures were, however, not efficiently applicable making more research into these novel phages and their mechanism of infection necessary. The existence of ...

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