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Study of the underlying mechanisms and consequences of pathogenicity differences between two in vitro selected G1-H9N2 clones originating from a single isolate.

pro-inflammatory cytokines and a lack of type I interferon production, whereas the mild disease outcome associated with the CEF-clone is related to a greater antiviral cytokine response. The immunosuppressive effect ...

European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the ...

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

anti-tuberculous drug from the same class. Although delamanid is found to inhibit cell wall synthesis, the expression of genes involved in this process were only mildly affected. In contrast, a clear parallel was ...

Personal exposure to traffic-related air pollutants and relationships with respiratory symptoms and oxidative stress: A pilot cross-sectional study among urban green space workers

highlights the value of this compound as well as exhaled NO and urinary 8- OH dG biomarkers to detect early/mild effects of air pollution. Service:  Évaluation des risques et de l'impact sur la santé ...

Global burden of intellectual disability resulting from prenatal exposure to methylmercury, 2015

Health Estimates methodology, and presented by 14 subregions. In 2015, the global total for MeHg-associated cases of ID was 226,655; 210,074 of these cases (93%) were mild cases of ID. The highest rate of ...

Quality of primary palliative care for older people with mild and severe dementia: an international mortality follow-back study using quality indicators.

and expert consensus. Subjects: patients aged 65 or older, who died non-suddenly with mild or severe dementia as judged by GP s (n = 874). Results: findings showed significantly different QI scores ...

Pre-exposure intradermal rabies vaccination: a non-inferiority trial in healthy adults on shortening the vaccination schedule from 28 to 7 days.

primary vaccination were mild and transient. Conclusion: In healthy adults, ID administration of a double dose of 0.1 ml of HDCV over two-visits (day 0 and day 7) was safe and not inferior to the ...

MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.

following intranasal infection with ERA, wild-type mice developed mild transient clinical signs with recovery at 35 DPI. Interestingly, MALT1-/- mice developed severe disease requiring euthanasia around 17 ...

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