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A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus.
alternative to pre-emptive culling or emergency vaccination we further explore the possibility to use antiviral drugs in the event of an FMD outbreak. In the present study, we tested the in vitro cytotoxicity ...
Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge.
infection. DNA plasmid-based vaccines represent a new approach for controlling infectious diseases. In rodents, DNA vaccines have been shown to induce B cell and cytotoxic T cell responses and protect against ...
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
the substituents on the two 1H-benzimidazole groups of BBP resulted in analogues equipotent in anti- BVDV activity (EC50 =0.7±0.1μM), devoid of cytotoxicity (S.I.=142). BBP resistant BVDV was selected ...
Absence of viral envelope proteins in equine herpesvirus 1-infected blood mononuclear cells during cell-associated viremia.
Keywords: Animals Cytotoxicity, Immunologic Herpesviridae Infections Herpesvirus 1, Equid Histocompatibility Antigens Class I Horse Diseases Horses Leukocytes, Mononuclear Viral Envelope Proteins Viremia ...
Necrotoxigenic Escherichia coli type-2 invade and cause diarrhoea during experimental infection in colostrum-restricted newborn calves.
that necrotoxigenic Escherichia coli (NTEC) strains producing the cytotoxic necrotising factor 1 cause intestinal and extra-intestinal disease in piglets. On the other hand, no experimental model has ...
Identification of DNA sequences recognized by VirF, the transcriptional activator of the Yersinia yop regulon.
Proteins Base Sequence DNA, Bacterial DNA-Binding Proteins Gene Expression Regulation, Bacterial Molecular Sequence Data Pore Forming Cytotoxic Proteins Promoter Regions, Genetic Protein Binding Protein ...