Search results - 49 results

Characterization and hazard identification of substandard and falsified antimicrobials encountered in Belgium

essential life-saving medicines could cause treatment failures, antimicrobial resistance and drug side effects [1]. Therefore, validated and robust analytical tools enabling the identification and ...

In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract

flavonoid aglycones (11.82%) and glycosides (16.17%). ADME, pharmacokinetic and drug-likeness assessment of major flavonoids of ELBE, using the web tool SwissADME, showed good oral bioavailability. The ...

Comparative dissolution study on substandard and falsified antibiotics encountered in Belgium

equivalences of dissolution profiles between SF antimicrobials and genuine products. The potential low drug efficacy induced by improper dissolution of SF antimicrobials could aggravate illness and even promote ...

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, ...

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid

incidence and counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

recent report of the WHO ranks tuberculosis (TB) alongside HIV as a leading cause of death by infectious diseases. In combination, the spread of (multi-)drug resistant Mycobacterium tuberculosis is rising ...

Innate signaling by mycolate esters of the cell wall of Mycobacterium tuberculosis and relevance for development of adjuvants for subunit vaccines

socioeconomic conditions, the increased incidence of drug-resistant M.tuberculosis strains and the co-infection with HIV (a major risk factor for development of TB). Currently only one vaccine is available against TB, the ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

(TB) alongside HIV as a leading cause of death by infectious diseases. In combination, the spread of (multi-)drug resistant Mycobacterium tuberculosis is rising (480 000 new cases), impeding the ...

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.

Issue 9, p.2215-29 (2016) Keywords: Carcinogens Cell Line, Tumor Computational Biology Dose-Response Relationship, Drug Gene Expression Profiling Gene Expression Regulation Genome-Wide Association Study ...

In vitro Dermal Absorption of Hydroquinone: Protocol Validation and Applicability on Illegal Skin-Whitening Cosmetics.

Source: Skin Pharmacol Physiol, Volume 29, Issue 6, p.300-308 (2016) Keywords: Adult Drug and Narcotic Control Female Humans Hydroquinones In Vitro Techniques Male middle aged Reproducibility of Results ...

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