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Retrospective surveillance of viable Bacillus cereus group contaminations in commercial food and feed vitamin B2 products sold on the Belgian market using whole-genome sequencing
common. All isolates carried multiple genes encoding virulence factors, including cytotoxin K-2 (52.78%) and cereulide (22.22%). Most isolates were predicted to be resistant to beta-lactam antibiotics ...
Use of near infrared spectroscopy and chemometrics for the classification of different Cannabis spp. samples found in Belgium
medicinal cannabis can both be purchased in a legal way, but cannabis to be used as recreational drug is illegal. Indeed, cannabis is the most widely consumed illicit drug in Europe and products contain ...
The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.
catalogue of mutations to serve as a global standard for interpreting molecular information for drug resistance prediction. Methods: A candidate gene approach was used to identify mutations as associated with ...
Retrospective evaluation of routine whole genome sequencing of Mycobacterium tuberculosis at the Belgian National Reference Center, 2019.
100% (pyrazinamide, PZA). The negative predictive value was above 95% for these four first-line drugs. A positive predictive value of 100% was calculated for INH and PZA, 80% for RIF and 45% for EMB. ...
Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.
Here, we evaluated the Deeplex Myc- TB targeted deep sequencing assay for prediction of resistance to 13 anti-tuberculous drugs/drug classes, directly applicable on sputum. With MTBC DNA tests, the limit ...
In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract
aglycones (11.82%) and glycosides (16.17%). ADME, pharmacokinetic and drug-likeness assessment of major flavonoids of ELBE, using the web tool SwissADME, showed good oral bioavailability. The protective ...
Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.
Organization priority. We previously developed a software tool,, which provided offline species identification and drug resistance predictions for from whole genome sequencing (WGS) data. Performance was ...
Falsification of biotechnology drugs: current dangers and/or future disasters?
Products Counterfeit Drugs Drug Contamination Humans Abstract: Falsified medical products have become a global threat since they were first mentioned to the general public at the conference of experts on the ...
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing
identified across nine genes, and individual phenotypes were predicted unless mutations of unknown association were also present. To identify how whole-genome sequencing might direct first-line drug therapy, ...
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Issue 9, p.2215-29 (2016) Keywords: Carcinogens Cell Line, Tumor Computational Biology Dose-Response Relationship, Drug Gene Expression Profiling Gene Expression Regulation Genome-Wide Association Study ...