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The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.
catalogue of mutations to serve as a global standard for interpreting molecular information for drug resistance prediction. Methods: A candidate gene approach was used to identify mutations as associated with ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
constructed and sequenced using the HiSeq technology (Illumina®). Reads were mapped to the reference genome and normalized read counts were calculated per gene. Results: For each drug a specific ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
(Illumina®). Reads were mapped to the reference genome and normalized read counts were calculated per gene. Results: For each drug a specific transcriptional response was mapped, revealing lists of up- and ...
RNA-based drug susceptibility testing of Mycobacterium tuberculosis
of resistance. Materials & Methods First, the global transcriptional response of two TB strains to 10 anti- TB drugs was determined using RNA taq-Seq. A set of highly responsive genes was selected for each ...
Transcriptional profiling of Mycobacterium tuberculosis suggests respiratory poisoning upon exposure to delamanid
from the same class. Although delamanid is found to inhibit cell wall synthesis, the expression of genes involved in this process were only mildly affected. In contrast, a clear parallel was found with ...