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The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRGTM cells
Source: EEMGS meeting, Malaga, Spain (2023) Keywords: benchmark dose modelling genotoxicity potency ranking transcriptomic biomarker Health Topics: Health and environment Santé et environnement Gezondheid ...
Development of an AOP-based IATA for genotoxicity
O Armant; C Pachoulide; H Bouwmeester; G Raitano; E Benfenati; E Wyrzykowska; M Stepnik; T Puzyn; M Audebert; Birgit Mertens Source: EEMGS meeting (2023) Keywords: adverse outcome pathways genotoxicity ...
Effects of long-term exposure to 50 Hz magnetic fields on cell viability, genetic damage, and sensitivity to mutagen-induced damage.
damage induced by known mutagens. At certain time points, statistically significant difference in genotoxicity test results were observed between the MF-exposed cells and the control cells. However, these ...
The GENOMARK biomarker inhuman HepaRGTM cells: a new approach methodology for genotoxicity assessment
SaferWorldByDesign webinar, Online (2023) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: Évaluation des risques et de ...
GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry
International cosmetic congress, Antalya, Turkey (2022) Keywords: genotoxicity NAM transcriptomic biomarker Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: Évaluation ...
Impact of experimental design factors on the potency of genotoxicants in in vitro test
Abstract: Previous studies have shown that differences in experimental design factors may alter the potency of genotoxic compounds in in vitro genotoxicity tests. Most of these studies used traditional ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells
(NAM s) to identify molecular events underlying the genotoxic mode of action of chemicals. Previously, we developed the GENOMARK biomarker, consisting of 84 genes selected based on whole genomics DNA ...
In Silico Methods for Chromosome Damage.
Keywords: Chromosome Aberrations Chromosomes DNA Damage Humans Mutagenicity Tests Mutagens Mutation Abstract: Due to the link with serious adverse health effects, genotoxicity is an important toxicological ...
In silico methods for chromosome damage
Issue 8, New York (2022) ISBN: 978-1-0716-1960-5 Abstract: Due to the link with serious adverse health effects, genotoxicity is an important toxicological endpoint in each regulatory setting with respect ...
Occurrence of (suspected) genotoxic flavoring substances in Belgian alcohol-free beers.
solvent-assisted flavor evaporation (SAFE) technique coupled to GC- MS (SIM) was developed and validated. Focus was put on authorized flavoring substances requiring specific attention due to a genotoxic concern ...