Search results - 26 results
Substandard and falsified ivermectin tablets obtained for self-medication during the COVID-19 pandemic as a source of potential harm.
One of the candidate antiviral medicines tested was ivermectin. Although several health authorities warned the public against the use of this medicine outside clinical trials, the drug was widely used ...
Microbial quality analysis of falsified medicines seized by controling agencies
have surged by nearly 65%, spanning 142 countries, posing significant threats to the health and well-being of unsuspecting individuals worldwide [100]. While substandard and falsified life-saving ...
Multidimensional chromatographic fingerprinting combined with chemometrics for the identification of regulated plants in suspicious plant food supplements
the Belgian Federal Agency for Medicines and Health Products, were classified using the above developed models. 10 out of 12 samples were suggestively found to be positive by binary modelling whereas 11 ...
COMBINATION OF CHEMOMETRICS AND MULTIDIMENSIONAL FINGERPRINTING FOR DETECTION OF REGULATED PLANTS IN PLANT FOOD SUPPLEMENTS
fingerprints by performing a correlation analysis on the DAD data. Chemometric analysis was carried out using two approaches: 1. binary models for each plant separately and 2. multiclass models. The data were ...
Multidimensional Chromatographic Fingerprinting Combined with Chemometrics for the Identification of Regulated Plants in Suspicious Plant Food Supplements.
were recorded using ultra-high-performance liquid chromatography (UHPLC) coupled with diode array detection (DAD). Chemometric modelling was performed by partial least squares-discriminant analysis (PLS- ...
Clustering of Tadalafil API Samples According to their Manufacturer in the Context of API Falsification Detection
falsified samples. In total, 46 tadalafil API samples from 13 different manufacturers were collected. For all samples fingerprint data was collected through analysis of impurities and residual solvents, mass ...
Multidimensional Fingerprint Development for the Detection of Tribulus terrestris in Plant Food Supplements
5 orthogonal wavelengths were selected. The developed method was tested for specificity in different triturations (½0, 1/15, 1/10, ⅕ and ½). These were prepared using 10 blank matrices and lactose. In most ...
CHROMATOGRAPHIC FINGERPRINT DEVELOPMENT FOR THE DETECTION OF TRIBULUS TERRESTRIS IN PLANT FOOD SUPPLEMENTS
by preparing triturations of TT with herbal matrices in varying ratios (½, ⅕, 1/10, 1/15, ½0). Twenty unknown samples were screened for TT and further confirmation was carried out by UH ¨ PLC-mass ...
Relative response factors and multiple regression models in liquid chromatography to quantify low-dosed components using alternative standards-proof of concept: total Δ9-THC content in cannabis flowers using CBD as reference.
classical RRF s, especially in the low-concentration ranges and that concentrations obtained with the LRRFM were in accordance with the interpolation results obtained with a calibration line. Health Topics: ...
OMCL testing and the API working group: Part of the solution?
trends, new frontiers, EDQM, Issue EDQM, Rome, Italy (0) Abstract: Within the OMCL network different initiatives were taken to augment the analysis and market surveillance of API s used by different ...