Search results - 298 results

In silico methods for chromosome damage

aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data without the need for test material, several in silico tools for chromosome damage have been ...

The bacteriophage LUZ24 "Igy" peptide inhibits the Pseudomonas DNA gyrase.

in vitro gyrase activity and interacts with the P. aeruginosa GyrB subunit, possibly by DNA mimicry, as indicated by a de novo model of the peptide and mutagenesis. In vivo, overproduction of Igy blocks DNA ...

Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative Diphenpipenol.

Piperazines Abstract: In this paper, the identification and full characterization of a novel non-fentanyl opioid sourced online, which is a member of the 1-substituted-4-(1,2-diphenylethyl)piperazine ...

Safety assessment of titanium dioxide (E171) as a food additive

between the physico-chemical properties of TiO2 particles and the outcome of either in vitro or in vivo genotoxicity assays. A concern for genotoxicity of TiO2 particles that may be present in E 171 could ...

Assessment of hazards and risks associated with dietary exposure to mineral oil for the Belgian population

scenarios, a health concern related to MOAH exposure could not be excluded, highlighting that more data are needed to perform an adequate risk assessment. The possibility to use in vitro bioassays to collect ...

Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide

the development of alternative testing strategies such as computational (predictive) models based on in vitro testing. However, the variations in in vitro experimental conditions can influence the ...

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

transhexanal, there was a clear concern for in vivo genotoxicity. A selection of 4 out of the remaining 22 flavourings was tested in two in vitro genotoxicity assays. Three out of the four tested flavourings ...

Chemical and toxciological characterization of e-liquid cigarettes

information on their genotoxicity was present. For four of these flavourings, a commercial standard was available and thus could be tested in vitro using an Ames- and micronucleus test. One of the four ...

Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative DiphenpipenolAbstract

Publication Type: Peer reviewed scientific article Authors: Annelies Cannaert; Hulpia, Fabian; Risseeuw, Martijn; Van Uytfanghe, Katleen; Eric Deconinck; Van Calenbergh, Serge; Peter Blanckaert; Stove, Christophe Source: Journal of Analytical Toxicology ( ...

QR code

QR code for this page URL