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Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep.

nontransformed counterparts. RESULTS: In the first animal, we observed the emergence of a genetically modified provirus simultaneously with leukemia onset. We found a Tax-mutated (TaxK303) replication-deficient provirus in the ...

Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants.

simultaneously three parameters: B-lymphocytosis, cell proliferation and viral replication. RESULTS: Sheep were experimentally infected either with a wild type BLV provirus or with selected mutants among which: ...

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