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Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

metabolism. Estimated human half-lives for PFOS and PFOA are about 5 years and 2?4 years, respectively. The derivation of a health-based guidance value was based on human epidemiological studies. For PFOS, the ...

Y-box-binding protein 1 supports the early and late steps of HIV replication.

decrease in virion production due to interference with the viral RNA metabolism. Using single-round virus infection experiments we demonstrated that early HIV-1 replication also depends on the cellular YB-1 ...

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

for pharmaceutical, chemical, and consumer products, as afflicted compounds have to be (prematurely) abandoned or further tested on animals. Using the metabolically competent human HepaRG ™ cell line and toxicogenomics ...

Genotoxicity studies on plant growth promoting smoke-water and smoke-derived compounds using Vicia faba and Persea americana S10 metabolic activation

Publication Type: Peer reviewed scientific article Authors: Partoens, M.; Kulkarni, M.G.; M.E. Light; J.C. Chukwujekwu; Luc Verschaeve; Van Staden, J. Source: South African Journal of Botany, Volume 115, Number 275 (2018) Health Topics:  Health and enviro ...

High coverage metabolomics analysis reveals phage-specific alterations to Pseudomonas aeruginosa physiology during infection.

Lavigne, Rob Source: ISME J, Volume 10, Issue 8, Number 1835, p.1823-35 (2016) Keywords: Genome, Viral Metabolomics Myoviridae Pseudomonas aeruginosa Pseudomonas Phages Abstract: Phage-mediated metabolic ...

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.

ase E. Through the activity of Dip, фKZ has evolved a unique mechanism to down regulate a key metabolic process of its host to allow accumulation of viral RNA in infected cells. Service:  Maladies ...

FabR regulates Salmonella biofilm formation via its direct target FabB.

putative direct targets (i.a. genes involved in tRNA metabolism, ribosome synthesis and translation). Next to UFA biosynthesis, a number of these direct targets and other indirect targets identified by ...

Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability.

cell function. METHODS: Biological and morphological methods (Ca(2+) imaging, Ca(2+) uptake, glucose metabolism, insulin release and immunohistochemistry) were used to assess beta cell function and proliferation ...

Relation between Spongy Bone Density in the Maxilla and Skeletal Bone Density.

Relat Res, Volume 17, Issue 6, p.1180-7 (2015) Keywords: Absorptiometry, Photon Aged Bone Density Bone Diseases, Metabolic Case-Control Studies Female Hip Humans Maxilla middle aged osteoporosis ...

Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents: the HELENA cross-sectional study

cardio-metabolic indicators (anthropometry and biomarkers). METHODS: The current analysis included 1804 randomly selected adolescents participating in the HELENA study (conducted in 2006-2007) aged 12.5-17.5 y (47% ...

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