Search results - 11 results

Is aggregated synthetic amorphous silica toxicologically relevant?

size distributions. Their effect on cell metabolic activity, cell viability, epithelial barrier integrity, total glutathione content and, IL-8 and IL-6 secretion were investigated after 24 h exposure in ...

Assessing the endocrine activity of PAHs using the DRE-, ERE- and PPARγ CALUX bioassays

presence of S9 metabolic fraction. Larger compounds like chrysene and benzo(ghi)perylene did not show any activity on the PPAR y receptor which may be the result of sterical hindrance preventing them to ...

Genotoxic evaluation of the liquids present in electronic cigarettes

b-phellandrene showed a slightly genotoxic effect in the in vitro micronucleus test in the presence of S9 metabolic fraction but was clearly negative in the Ames test. In contrast, 2,3-pentanedione induced a clear ...

Migration of mineral oil from cardboard packaging for food: Identification of the hazards and assessment of the exposure of the Belgian population

obtained, including further evidence that highly alkylated polycyclic aromatic hydrocarbons (PAH s) (which are important constituents of the MOAH fraction) are not metabolized into DNA ‐reactive compounds due ...

Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.

successful marker was a Shigella-specific deletion in the spermidine acetyltransferase gene speG, reflecting its metabolic decay. For Shigella serotype prediction, the multiplex assay scored a sensitivity and ...

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

do not undergo metabolism. Estimated human half-lives for PFOS and PFOA are about 5 years and 2?4 years, respectively. The derivation of a health-based guidance value was based on human epidemiological ...

Y-box-binding protein 1 supports the early and late steps of HIV replication.

to 5-fold decrease in virion production due to interference with the viral RNA metabolism. Using single-round virus infection experiments we demonstrated that early HIV-1 replication also depends on ...

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

for pharmaceutical, chemical, and consumer products, as afflicted compounds have to be (prematurely) abandoned or further tested on animals. Using the metabolically competent human HepaRG ™ cell line and toxicogenomics ...

Genotoxicity studies on plant growth promoting smoke-water and smoke-derived compounds using Vicia faba and Persea americana S10 metabolic activation

Publication Type: Peer reviewed scientific article Authors: Partoens, M.; Kulkarni, M.G.; Light, M.E.; Chukwujekwu, J.C.; Luc Verschaeve; Van Staden, J. Source: South African Journal of Botany, Volume 115, Number 275 (2018) Health Topics:  Health and envi ...

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