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Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

DNA microarray profiles of 24 (non-)genotoxic reference chemicals covering different modes of action in metabolically competent human HepaRG™ cells. In the present study, new prediction models for ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells

microarray profiles of 24 (non-)genotoxic reference chemicals covering different modes of action in metabolically competent human HepaRG™ cells. In the present study, new prediction models for genotoxicity ...

Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water

(PPIIA), disrupting cell growth and metabolism [15,16]. When ingested, these toxins are transported by the bile salts to the liver, potentially causing liver damage [17,18,19]. Health Topics:  Food ...

Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial

Ampe; Vangoitsenhoven, Roman; Ann Mertens; Rudi Vennekens; Van der Schueren, Bart Source: European Journal of Drug Metabolism and Pharmacokinetics, Volume 47, Issue 6 (2022) Abstract: Background ...

Risk factors and their contribution to population health in the European Union (EU-28) countries in 2007 and 2017

2017, behavioural and metabolic risk factors showed a higher attributable burden compared with environmental risks, with tobacco, dietary risks and high systolic blood pressure standing out. While tobacco ...

Effect of an Integrated, Multidisciplinary Nationwide Approach to Type 1 Diabetes Care on Metabolic Outcomes: An Observational Real-World Study

Publication Type: Peer reviewed scientific article Authors: Astrid Lavens; Nobels, Frank; C. De Block; Philippe Oriot; Ann Verhaegen; Suchsia Chao; Kristina Casteels; Thierry Mouraux; Kris Doggen; Mathieu, Chantal Source: Diabetes Technology & Therape ...

Is aggregated synthetic amorphous silica toxicologically relevant?

size distributions. Their effect on cell metabolic activity, cell viability, epithelial barrier integrity, total glutathione content and, IL-8 and IL-6 secretion were investigated after 24 h exposure in ...

In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract

effect of ELBE against AFB1 induced genotoxicity in the Vitotox assay after metabolic activation was confirmed (IC50 of 44.32 μg/ml), followed by evaluation of its inhibitory effect on hepatotoxicity in ...

Shifting national surveillance of Shigella infections toward geno-serotyping by the development of a tailored Luminex assay and NGS workflow.

a Shigella-specific deletion in the spermidine acetyltransferase gene speG, reflecting its metabolic decay. For Shigella serotype prediction, the multiplex assay scored a sensitivity and specificity of 96.6% and 98.4%, ...

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