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Assessing the endocrine activity of PAHs using the DRE-, ERE- and PPARγ CALUX bioassays

presence of S9 metabolic fraction. Larger compounds like chrysene and benzo(ghi)perylene did not show any activity on the PPAR y receptor which may be the result of sterical hindrance preventing them to ...

In vitro antigenotoxic activity, in silico ADME prediction and protective effects against aflatoxin B1 induced hepatotoxicity in rats of an Erythrina latissima stem bark extract

effect of ELBE against AFB1 induced genotoxicity in the Vitotox assay after metabolic activation was confirmed (IC50 of 44.32 μg/ml), followed by evaluation of its inhibitory effect on hepatotoxicity in ...

Genotoxic evaluation of the liquids present in electronic cigarettes

b-phellandrene showed a slightly genotoxic effect in the in vitro micronucleus test in the presence of S9 metabolic fraction but was clearly negative in the Ames test. In contrast, 2,3-pentanedione induced a clear ...

Migration of mineral oil from cardboard packaging for food: Identification of the hazards and assessment of the exposure of the Belgian population

results were obtained, including further evidence that highly alkylated polycyclic aromatic hydrocarbons (PAH s) (which are important constituents of the MOAH fraction) are not metabolized into DNA ...

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