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Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants.

a mutation such as E119V- NA is known, highly sensitive PCR-based genotypic assays can be used to identify the prevalence of such mutant influenza viruses in clinical samples. In this study, based on an ...

Next-Generation Sequencing: An Eye-Opener for the Surveillance of Antiviral Resistance in Influenza

antivirals can lead to antiviral resistance mutations in the entire influenza genome. Therefore, the methods to detect these mutations should be developed and implemented. In this Opinion, we assess how NGS ...

Incorporation of the influenza A virus NA segment into virions does not require cognate non-coding sequences.

restored. Sequencing revealed that the replacing 5' NC sequence length drove the type of mutations obtained. With sequences longer than the original, point mutations in the coding region with or without ...

Overlapping signals for translational regulation and packaging of influenza A virus segment 2.

mutated AUG s 1-4 and monitored polypeptide synthesis from plasmids and recombinant viruses. This identified sORF2 as a key regulatory element with opposing effects on PB1- F2 and PB1- N40 expression. We ...

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