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Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
relationships of a series of 1,2,4-oxadiazole EthR inhibitors leading to the discovery of potent ethionamide boosters. Despite high metabolic stability, pharmacokinetic evaluation revealed poor mice exposure; ...
Does country influence the health burden of informal care? An international comparison between Belgium and Great Britain36539
socioeconomically similar. These pairs of areas are then used as fixed effects in logistic regressions of poor health. This allows us to take into account the influence of area type on health and to remove the ...
The expression and role of CXC chemokines in colorectal cancer
CXCL16) and their receptors (CXCR1 to CXCR6) in colorectal cancer. Overall, increased expression levels of CXC chemokines correlate with poor prognosis Service: Qualité des laboratoires Kwaliteit van ...
Overlapping signals for translational regulation and packaging of influenza A virus segment 2.
and replicated poorly, producing virions with elevated particle: PFU ratios. Analysis of the genome content of virus particles showed reduced packaging of the mutant segment 2 vRNAs. Overall, we ...
Short rotation coppice culture of willows and poplars as energy crops on metal contaminated agricultural soils.
study was to investigate the possibilities of growing willows and poplars under short rotation coppice (SRC) on an acid, poor, sandy metal contaminated soil, to combine in this way soil remediation by ...
Risk factors for ceftiofur resistance in Escherichia coli from Belgian broilers.
farm level, besides antimicrobial use, seven management factors were found to be associated with the occurrence of ceftiofur resistance in E. coli from broilers: poor hygienic condition of the medicinal ...
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules36549
three identical VHH) and biparatopic (two different VHH) constructs. By combining a VHH neutralizing RSV subtype A, but not subtype B with a poorly neutralizing VHH with high affinity for subtype B, ...
A non-invasive intranasal inoculation technique using isoflurane anesthesia to infect the brain of mice with rabies virus.
often described poorly and the effects of variations in the technique on the outcome are unknown. Standardization of protocols is key to compare studies and minimize animal use. The clinical and ...
Overall and within-food group diversity are associated with dietary quality in Belgium.
recommendation for the intake of that food group. An inverse association was found between dietary diversity within the meat and the energy-dense, nutrient-poor food groups and dietary balance. Diversity within ...
Unusual Aspergillus species in patients with cystic fibrosis36887
public public health Public-health Pulmonary Aspergillosis report reports routine Sample Samples SB- IM Sequence Analysis Sequence Analysis,DNA Species Specificity sputum study Temperature Abstract: Poorly ...