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Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.
inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as ...
Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid
delamanid. Remarkably, the most highly induced genes comprise poorly characterized genes for which functional characterization might hint to the target molecule(s) of delamanid and its exact mode(s) of action. ...
Development and validation of chromatographic methods for screening and subsequent quantification of suspected illegal antimicrobial drugs encountered on the Belgian market
Among them, antibiotics and antimalarials are the most commonly reported since 2013. Besides the fact that falsification is a crime, the worldwide use of poor quality antimicrobials could result in ...
Sera from different age cohorts in Belgium show limited cross-neutralisation between the mumps vaccine and outbreak strains
titres for the vaccine and wild type virus for all younger age groups, except 24-26y, were significantly different, demonstrating poor in vitro cross-neutralisation. CONCLUSIONS: A possible contribution of ...
Multivalent binding of herpesvirus to living cells is tightly regulated during infection.
efficient release of progeny virions from the cell surface. However, so far, the molecular mechanisms underlying the regulation of the multivalency in virus attachment to receptors are poorly understood. We ...
Changes in health in Belgium, 1990-2016: a benchmarking analysis based on the global burden of disease 2016 study
Keywords: Belgium Benchmarking burden disease Abstract: BACKGROUND: Despite increasing of the Belgian health expenditures, several indicators related to population health showed poor results. The objectives ...
Performance of in silico models for mutagenicity prediction of food contact materials
predict the mutagenic potential of substances that are new to the model (i.e. not included in the training set) is reported. In this context, the generally poor sensitivity for these new substances is ...
Multinomial additive hazard model to assess the disability burden using cross-sectional data.
Population aging is accompanied by the burden of chronic diseases and disability. Chronic diseases are among the main causes of disability, which is associated with poor quality of life and high health care ...
Migrant's access to preventive health services in five EU countries.
for non- EU migrants. CONCLUSIONS: The findings of this study are in accordance with evidence from the scientific literature. Poor organization of health services, in Italy, and lack of targeted health ...
Effect of allergic bronchopulmonary aspergillosis on FEV1 in children and adolescents with cystic fibrosis: a European Cystic Fibrosis Society Patient Registry analysis.
significant (p>0.05). For patients aged 11.82 years (population mean age), poor body mass index had the greatest impact on FEV1 in 2008, followed by high-risk genotype (two severe mutations), female gender, ...