Search results - 8 results

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

other tools on 10207 (=5845+4362) samples, and also show that gives concordant results with nanopore data.  We measure the ability of-based DST to guide personalized therapeutic regimen design in the ...

Strong increase of true and false positive mycobacterial cultures sent to the National Reference Centre in Belgium, 2007 to 2016.

(1,097/2,534) of all samples in 2016.ConclusionWe recommend inclusion of NTM in sentinel programmes. The large increase of false positive cultures is hypothesised to result from processing issues prior to arrival ...

Time-and-motion tool for the assessment of working time in tuberculosis laboratories: a multicentre study.

objective means for recording the actual time spent on running laboratory assays. DESIGN: Multicentre prospective study conducted in six European Union (EU) reference TB  laboratories. RESULTS: A total of ...

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

cases, carbapenems have been studied in vitro and in animal models, with encouraging results. However, only short-term follow-up data from clinical studies are currently available. OBJECTIVES: To study the ...

MALDI-TOF for the identification of Mycobacteria and their drug resistance profiles

BACTEC MGIT results. Moreover, incubation with serial dilutions allowed a correct determination of the Minimal Inhibitory Concentrations of isoniazid and rifampicin. Therefore, this method has the ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

constructed and sequenced using the HiSeq technology (Illumina®). Reads were mapped to the reference genome and normalized read counts were calculated per gene.   Results: For each drug a specific ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

(Illumina®). Reads were mapped to the reference genome and normalized read counts were calculated per gene.   Results: For each drug a specific transcriptional response was mapped, revealing lists of up- and ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

Fisher) technology. The normalized expression levels are combined to one numeric value which determines the drug susceptibility of the investigated strain. Results We successfully developed 8 primary sets ...

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