Search results - 7 results

Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs.

isolates, the assay predicted 92.2% of 2369 first- and second-line phenotypes, with a sensitivity of 95.3% and specificity of 97.4%. Fifty-six of 69 (81.2%) residual discrepancies with phenotypic results ...

Molecular surveillance of anti-malarial drug resistance in Democratic Republic of Congo: high variability of chloroquinoresistance and lack of amodiaquinoresistance.

detected by a rapid diagnostic test (RDT) available on site (SD Bioline Malaria Ag Pf or CareStart Malaria Pf) or thick blood smear and then confirmed by a P. falciparum species-specific real-time PCR assay. ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

pump overexpression, and (d) ignore the multifactorial influence of compensatory mutations. Here, we introduce a next-generation diagnostic test based on quantification of antibiotic-specific RNA ...

Poor adherence to guidelines for preventing central line-associated bloodstream infections (CLABSI): results of a worldwide survey.

CLABSI rate. Heterogeneity between countries was high and country specific results are made available. CONCLUSIONS: This study has identified areas for improvement in CLABSI prevention practices linked to ...

Epidemiology of Clostridium difficile infection in Belgium: Report 2014

attained a peak in 2004, (linked particularly to an enormous increase in Brussels) subsequently followed by a decline. In 2010, the crude specific mortality rate for CDI in Belgium was 0.9 /100 000 ...

Phage–Host Protein–Protein Interactions Using Strep-tag® II Purifications

efficient phage production. For this, specific proteins have evolved which interact with key host proteins to inhibit, activate or redirect the function of these proteins. Since 70% of the currently annotated ...

The Phage-Encoded-Acetyltransferase Rac Mediates Inactivation of Transcription by Cleavage of the RNA Polymerase Alpha Subunit.

mediates the inactivation of bacterial transcription by introducing a specific cleavage in the α subunit of the bacterial RNA polymerase. This cleavage occurs within the flexible linker sequence and ...

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