Search results - 7 results

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

107/15,667 (0·7%) were deemed consistent with susceptibility. For rifampicin, isoniazid, ethambutol, fluoroquinolones, and streptomycin, the mutations’ pooled sensitivity was >80%. Specificity was over 95% ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

sensitive and 99%, 100%, 99%, 99% specific for rifampicin, isoniazid, pyrazinamide and ethambutol resistance prediction respectively. We benchmark against four other tools on 10207 (=5845+4362) samples, and ...

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

included in the analysis. The successful outcome and mortality rates were respectively 83.3% and 11.1%. No relapses were observed in cured patients after a median follow-up of 4 years. No specific adverse ...

Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection

lungs, spleen and liver and mycobacteria specific spleen cell IFN-γ, IL-10 and IL-17 production as well as serum antibody responses were analyzed. Isolates varied in virulence, with human and porcine ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

Moreover, comparing the response of sensitive and resistant strains can yield additional information, like the activation of specific efflux pumps. However, due to the high cost of RNA seq analyses, genome ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

sensitive and resistant strains can yield additional information, like the activation of specific efflux pumps. However, due to the high cost of RNA seq analyses, genome wide transcriptional analyses of drug ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

a next-generation diagnostic test based on quantification of drug-specific RNA biomarkers. The basic principle is that a brief antibiotic exposure triggers specific transcriptional responses in susceptible, but not ...

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