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Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions

Uhlrich; Rob J. Vandebriel Source: Toxins, Volume 14, Issue 1 (2022) Health Topics:  Effectiveness and safety of vaccines, medicines and health products- Quality of medical laboratories Efficacité et ...

Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production

vaccine production. One of the major critical points in the manufacturing of these vaccines is the stable and reproducible production of high levels of toxin by the bacterial seed strains. In order to ...

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