Search results - 13 results

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

catalogue of mutations to serve as a global standard for interpreting molecular information for drug resistance prediction. Methods: A candidate gene approach was used to identify mutations as associated with ...

Multicentre study on the reproducibility of MALDI-TOF MS for nontuberculous mycobacteria identification.

anonymized and sent out to the 15 participating laboratories. Isolates were identified using MALDI Biotyper (Bruker Daltonics). Up to 1330 MALDI- TOF identifications were collected in the study. A score ≥ 1.6 ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

insufficient to support the use of WGS as an alternative to conventional phenotype-based DST, due to mutation catalogue limitations.  Here we present a new tool,, which provides the same functionality based on ...

Time-and-motion tool for the assessment of working time in tuberculosis laboratories: a multicentre study.

1060 specimens were tested using four laboratory assays. The number of specimens per batch varied from one to 60; a total of 64 recordings were performed. Theoretical hands-on times per specimen (TTPS) ...

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

isolates and clustered them using a threshold of five single nucleotide polymorphisms (SNP s). We collated epidemiological data from host countries from the European Centre for Disease Prevention ...

Meropenem-clavulanate for drug-resistant tuberculosis: a follow-up of relapse-free cases.

at least rifampicin, isoniazid, any fluoroquinolone and one of the injectable anti-tuberculosis drugs, remains a worldwide public health threat. Among repurposed drugs empirically used for XDR- TB ...

Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection

Abstract: Mycobacterium avium subsp. hominissuis (Mah) represents a health concern for humans and to a lesser extent for pigs, but its zoonotic potential remains elusive. Using multispacer sequence typing ...

MALDI-TOF for the identification of Mycobacteria and their drug resistance profiles

MALDI- TOF MS and outcomes vary from 55% correct identifications to 97%2-4. In this study, we optimized an extraction protocol and evaluated its efficiency using the Brüker Biotyper system v3.0 for 194 ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

(480 000 new cases), impeding the treatment of infected patients. Current TB drug resistance research is mainly focused on the genomic level, using WGS to search for resistance-causing mutations. ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

treatment of infected patients. Current TB drug resistance research is mainly focused on the genomic level, using WGS to search for resistance-causing mutations. However, transcriptional analyses can be ...

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