A limited role for SsrA/B in persistent Salmonella Typhimurium infections in pigs36796

Last updated on 22-8-2019 by Anonymous (non vérifié)

Public Access


Peer reviewed scientific article


Virulence genes regulated by the SsrA/B system are indispensable for systemic disease in BALB/c mice. The role of this regulating system in the pathogenesis of Salmonella Typhimurium infections in pigs is not documented. In the present study, the interactions of Salmonella Typhimurium and an ssrA/B mutant were compared in vitro and in vivo. The ssrA/B mutant strain displayed decreased Salmonella Pathogenicity Island 2 (SPI-2) expression levels, showed a replication defect in mouse macrophages and was attenuated in a mouse model after oral inoculation. Using real time qRT-PCR and a porcine i…

Associated health topics:

QR code

QR code for this page URL