Last updated on 21-2-2023 by Pauline De Wurstemberger
Auteurs
Cindy Simoens; Gheit, Tarik; Ridder, Ruediger; Gorbaslieva, Ivana; Holzinger, Dana; Lucas, Eric; Rehm, Susanne; Vermeulen, Peter; Lammens, Martin; Vanderveken, Olivier; Kumar, Rekha Vijay; Gangane, Nitin; Caniglia, Alessandro; Maffini, Fausto; Lloveras Rubio, Maria Belén; Anantharaman, Devasena; Chiocca, Susanna; Brennan, Paul; Pillai, Madhavan Radhakrishna; Sankaranarayanan, Rengaswamy; Bogers, Johannes; Pawlita, Michael; Tommasino, Massimo; M. ArbynMots-clés
Résumé:
Background
The incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing in high-resource countries. Patients with HPV-induced cancer respond better to treatment and consequently have lower case-fatality rates than patients with HPV-unrelated OPC. These considerations highlight the importance of reliable and accurate markers to diagnose truly HPV-induced OPC.
Methods
The accuracy of three possible test strategies, i.e. (a) hrHPV DNA PCR (DNA), (b) p16(INK4a) immunohistochemistry (I…