Comparison of biological activities of natural and recombinant chicken interferon-gamma.

Last updated on 22-8-2019 by Anonymous (non vérifié)

Peer reviewed scientific article



In recent years, chicken interferon-gamma (ChIFN-gamma) has been identified and cloned from a chicken T cell line. In this study, recombinant ChIFN-gammma produced in the baculovirus and prokaryotic (Escherichia coli) expression systems were characterized and their activity was compared to that of naturally ChIFN-gamma produced by mitogen-activated splenic T cells. The baculovirus-derived ChIFN-gamma protein (Bac-ChIFN-gamma) proved to have physiochemical properties and biological activities similar to those of natural ChIFN-gamma. Indeed, Bac-ChIFN-gamma was able to inhibit the replication…

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