TY - JOUR T1 - Risk factors for methicillin resistant Staphylococcus aureus: a multi-laboratory study JF - PLoS.One. Y1 - 2014 A1 - Boudewijn Catry A1 - Katrien Latour A1 - Jans, B A1 - Vandendriessche,S. A1 - Preal, R A1 - Karl Mertens A1 - O. Denis KW - Antimicrobial resistance KW - Staphylococcus aureus AB -

BACKGROUND: The present study aimed to investigate the dose response relationship between the prescriptions of antimicrobial agents and infection/colonization with methicillin resistant Staphylococcus aureus (MRSA) taking additional factors like stay in a health care facility into account. METHODS: Multi-centre retrospective study on a cohort of patients that underwent microbiological diagnostics in Belgium during 2005. The bacteriological results retrieved from 17 voluntary participating clinical laboratories were coupled with the individual antimicrobial consumption patterns (July 2004-December 2005) and other variables as provided by pooled data of health insurance funds. Multivariate analysis was used to identify risk factors for MRSA colonization/infection. RESULTS: A total of 6844 patients of which 17.5% died in the year 2005, were included in a logistic regression model. More than 97% of MRSA was associated with infection (clinical samples), and only a minority with screening/colonization (1.59%). Factors (95% CI) significantly (p

VL - 9 CP - 2 U1 -

31134

M3 - http://dx.doi.org/10.1371/journal.pone.0089579 ER -