TY - JOUR T1 - Nosocomial Intravascular Catheter Infections with Extended-spectrum Beta-lactamase-producing Escherichia coli in Calves after Strain Introduction from a Commercial Herd JF - Transbound.Emerg.Dis. Y1 - 2015 A1 - Pardon,B. A1 - Smet,A. A1 - Butaye,P. A1 - Argudin,M.A. A1 - Valgaeren,B. A1 - Boudewijn Catry A1 - Haesebrouck,F. A1 - Deprez,P. KW - a KW - admission KW - ALL KW - an KW - Animal KW - Animals KW - Antimicrobial KW - Antimicrobial resistance KW - antimicrobial use KW - article KW - bacteria KW - Belgium KW - Brussels KW - care KW - Case KW - Catheter-Related Infections KW - clinic KW - danger KW - disease KW - Diseases KW - dissemination KW - e KW - electronic KW - Electrophoresis KW - environment KW - Escherichia coli KW - evidence KW - Faculty KW - food KW - gene KW - health KW - health care KW - Health care associated KW - HEALTH-CARE KW - hospital KW - Hospitalization KW - immunology KW - INFECTION KW - infections KW - Institute KW - internal medicine KW - IS KW - journal KW - Medicine KW - mortality KW - NEONATAL KW - nosocomial KW - ON KW - ORIGIN KW - outbreak KW - pathology KW - public KW - public health KW - Public-health KW - report KW - resistance KW - strain KW - teaching KW - Universities KW - university KW - use KW - veterinary KW - Veterinary Medicine KW - WIV-ISP AB - An outbreak of intravascular catheter-related infections by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in calves in an animal teaching hospital is reported. Pulsed-field gel electrophoresis was used for strain typing to determine the origin and dissemination of these strains. All 19 strains harboured the blaCTX -M-14, and six strains also overexpressed their chromosomal AmpC gene. Evidence on the introduction of the strain from a beef herd, experiencing neonatal diarrhoea and increased mortality, to the clinic through admission of diarrhoeic calves was provided. Strains isolated from phlebitis cases from other herds up to 5 months later showed a high similarity with the initial strain, suggesting that the strain had become nosocomial. The catheter infections with ESBL/AmpC-producing E. coli resulted in a prolonged hospitalization, increased anti-microbial use and mortality. This report points towards the potential dangers of the emergence of ESBL/AmpC-producing bacteria in susceptible food animals and warns farmers and veterinarians for the facility by which they are introduced into another environment VL - tbc CP - tbc U1 - 31585 M3 - http://dx.doi.org/10.1111/tbed.12352 ER -